Granville, David

Portrait photo of David Granville


Granville, David

PhD (Brit. Col.)

Basic Info

Academic Rank:



Centre for Heart Lung Innovation UBC, St. Paul’s Hospital



Short Bio

Dr. David Granville is a Professor and Associate Dean, Research in the UBC Faculty of Medicine. He is also the Executive Director of the Vancouver Coastal Health Research Institute, the largest hospital-based research institute in Western Canada. He is a Principal Investigator at the ICORD Centre, the UBC Centre for Heart Lung Innovation and is the Director of the BC Professional Firefighters’ Burn and Wound Healing Research Group. Dr. Granville previously worked at QLT, Inc. (1994-2001) where his R&D studies supported the approval of Visudyne® to be used as the first treatment for macular degeneration, the leading cause of blindness in the elderly. In 1999 Visudyne® was approved by the FDA resulting in the largest ophthalmic product release in history. Dr. Granville’s research is referred to on the drug label for Visudyne®. In 2001, Dr. Granville moved to Scripps where he discovered a novel therapeutic target for attenuating ischemic heart injury related to myocardial infarction and transplantation, which led to the formation of Radical Therapeutix (San Diego, CA). He was recruited back to UBC as an Assistant Professor, Canada Research Chair and MSFHR Scholar to work at the UBC Centre for Heart Lung Innovation (2003-2016). In 2016 he relocated to the ICORD Centre/VCHRI/UBC. Dr. Granville has received numerous awards including a Michael Smith Foundation for Health Research Scholar Award, Canada Research Chair, Canada Top 40 Under 40 Award, Business in Vancouver Top Forty Under 40, Canadian Association of Pathology Scientist Award, UBC Outstanding Young Alumnus Award, SFU Academic Alumnus Award, and was a runner-up for the American Heart Association Louis and Arnold Katz Basic Science Prize. He is also a Scholar of the Royal Society of Canada and a Fellow of the American Heart Association. His current research is focused on mechanisms of tissue injury, inflammation and repair and how aging and dysregulated inflammation affect tissue integrity, repair and remodelling. His recent research has led to the formation of the UBC-spin-off company, viDA Therapeutics of which he is a co-Founder and Chief Scientific Officer.

  • Executive Director, Vancouver Coastal Health Research Institute (VCHRI)
  • Associate Dean, Research – VCHRI, Faculty of Medicine, UBC
  • Associate Director, BC Professional Firefighters’ Burn and Wound Healing Research Laboratory, Division of Plastic Surgery, Department of Surgery, UBC
  • Principal Investigator, UBC ICORD
  • Principal Investigator, UBC Centre for Heart Lung Innovation, St. Paul’s Hospital
  • Associate Member, Department of Surgery, UBC
  • Affiliated Member, CIHR Skin Research Training Centre, UBC
  • Adjunct Professor, Institute of Molecular Biology and Biochemistry, Simon Fraser University
  • Co-Founder and Chief Scientific Officer, viDA Therapeutics Inc.


Academic Backgrounds

  • PDF, The Scripps Research Institute, Molecular and Experimental Medicine. 2003
  • PhD, The University of British Columbia, Pathology and Laboratory Medicine. 2001
  • BSc, Simon Fraser University, Biological Sciences. 1994

Awards & Recognition

Some of Dr. Granville’s major awards and accomplishments include:

  • Tier II Canada Research Chair
  • Michael Smith Foundation for Health Research Scholar
  • Young Investigator Award, Canadian Society of Transplantation
  • Wilbert J. Keon Award for Basic Science Finalist
  • Canada Top 40 Under 40 Award
  • Outstanding Young Alumnus Award, University of British Columbia
  • American Heart Association – Louis N and Arnold M Katz Basic Science Research Prize Finalist
  • Outstanding Alumni Award for Academic Achievement, Simon Fraser University
  • Canadian Association of Pathologists Junior Scientist Award
  • Business in Vancouver Forty Under 40 Award
  • Fellow of the American Heart Association
  • Scholar of the College of New Scholars, Artists and Scientists of the Royal Society of Canada

Selected Publications


Current Openings & Opportunities

Although his laboratory is quite full at the moment, Dr. Granville is always on the lookout for talented, energetic and bright graduate students and post-doctoral fellows to join his team if funding is available. Please contact Dr. Granville with inquiries.

Current Projects In My Lab include


Aging; Cardiovascular health; dermatology; extracellular matrix; Granzymes; inflammation; proteases; Pulmonary health; remodelling; Repair; Tissue injury; Wound healing

Over the past 20 years, Dr. Granville’s research program has focused on identifying mechanisms that underlie tissue injury and therapeutic targets that can be exploited to reduce injury and/or promote healing. His research is presently centered on how aging and immobility affect tissue injury, inflammation, and repair in different types of tissues. Dr. Granville’s research team is investigating a family of immune cell-secreted proteases known as granzymes (granule-secreted enzymes) and their role in aging and chronic inflammation. Dr. Granville identified that granzymes are elevated and contribute to the pathogenesis of conditions associated with impaired healing and inflammation, including skin injuries, autoimmune skin diseases, and cardiovascular and pulmonary diseases. In order to study granzymes in a diverse set of indications, Dr. Granville collaborates with a network of expert clinical and scientific collaborators. Dr. Granville is currently translating his discoveries into the development and commercialization of novel, first-in-class therapeutics.

At ICORD, Dr. Granville’s team is expanding on their discoveries in tissue injury, inflammation, and repair, and applying their expertise to spinal cord injury, pressure injury, dermatological conditions, and aging-related disorders. Dr. Granville also continues to lead an established research program examining the role of granzymes in cardiovascular and pulmonary diseases. Dr. Granville’s team is currently one of few groups in the world studying granzyme K in inflammation and disease.