Academic Rank:
Professor
Co-Director, Institute for Heart + Lung Health (IHLH)
CEO, Prevention of Organ Failure Centre of Excellence (PROOF Centre)
Active Staff, Department of Pathology & Laboratory Medicine, St. Paul’s Hospital
Affiliation(s):
Centre for Heart Lung Innovation
Prevention of Organ Failure Centre of Excellence (PROOF Centre)
Location:
St. Paul’s Hospital

Short Bio:

Bruce McManus is Professor, Department of Pathology and Laboratory Medicine, at the University of British Columbia. He serves as the Director of the NCE CECR Centre of Excellence for Prevention of Organ Failure (PROOF Centre), as Co-Director of the Institute for Heart + Lung Health, and as Immediate-Past Director, UBC James Hogg Research Centre. Dr. McManus served as the inaugural Scientific Director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, from December 2000 until April 2006.

Dr. McManus received BA and MD degrees at the University of Saskatchewan, an MSc in Applied Physiology from Pennsylvania State University, and PhD in Exercise Physiology and Biochemistry from the University of Toledo. He pursued post-doctoral fellowships in Environmental Physiology at the University of California – Santa Barbara and in Cardiovascular and Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, MD. Residency training at the Peter Bent Brigham Hospital – Harvard University in Internal Medicine and Pathology, was followed by specialization in Cardiovascular Pathology. After 11 years as a faculty member at the University of Nebraska Medical Centre, including a sabbatical as John F. Fogarty Senior International Fellow at the Max Planck Institute for Biochemistry, Martinsried, Germany, Dr. McManus joined the Faculty of Medicine of the University of British Columbia as Department Head of Pathology and Laboratory Medicine in July 1993, a post he held until December, 2000. Dr. McManus is a Fellow of the Royal College of Physicians and Surgeons of Canada, the College of American Pathologists, the American College of Cardiology, and the American College of Chest Physicians.

Dr. McManus’ basic and clinical investigative program is focused on mechanisms, consequences, detection and prevention of injury and aberrant repair involved in inflammatory diseases of the heart and blood vessels, with particular emphasis on enteroviral infections of the heart and transplant vascular disease. He works in a cross-disciplinary setting on translational research questions for which answers are critically enabled by computational sciences including molecular biomarker discovery and validation, information acquisition, annotation, and use, and registry development to support heart and lung research. Dr. McManus has co-authored ~350 peer-reviewed publications, as well as many chapters. He has edited four books. He is co-holder of numerous patents. He has served as Councilor for the International Society for Heart Research and for the American Society for Investigative Pathology. He is past-president of the Society for Cardiovascular Pathology. He currently serves on editorial boards of several professional and scientific journals, and on many advisory committees and boards. He has long been committed to training and mentoring scientist trainees across a range of disciplines. He has convened many public and private sector partnerships in research.

Dr. McManus has been recognized for his scientific contributions by numerous institutions and organizations through visiting professorships and lectureships. He was co-recipient of the prestigious Max Planck Research Award in 1991. He was elected to the Royal Society of Canada as a Fellow of the Academy of Sciences in 2002. He received a UBC Killam Research Prize – Senior Scientist Category in 2003. In 2005, he was elected as an inaugural Fellow of the Canadian Academy of Health Sciences and was honoured with the Research Achievement Award of the Canadian Cardiovascular Society. In 2006 Dr. McManus received the BC Innovation Council’s Lieutenant Governor’s Technology Innovation Award. He has been honored with the 2007 UBC Distinguished Medical Lecturer Award and 2008 David F. Hardwick Lifetime Achievement Award. He was awarded the 2009 CSATVB Scientific Excellence Award, Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology. Dr. McManus has been recognized by the Society for Cardiovascular Pathology with the 2010 Distinguished Achievement Award and by Providence Health Care with the 2010 Research & Mission Award. Recently, he received the 2012 Milton Wong Leadership Award from LifeSciences BC, the 2012 Aubrey J. Tingle Prize from the Michael Smith Foundation for Health Research, and the 2012 Alumni Achievement Award from the University of Saskatchewan.

Academic Backgrounds:
  • University of Saskatchewan MD Medicine. 1973-1977
  • University of Toledo PhD Exercise Physiology and Biochemistry. 1969-1972
  • Pennsylvania State University MSc Exercise Physiology. 1967-1969
  • University of Saskatchewan BA Biology and Physical Education. 1963-1967

 

Professional Qualifications

  • Fellowship, Royal College of Physicians and Surgeons (Pathology). Sept 1993
  • Medical Licensure: British Columbia. Aug 1993
  • Medical Licensure: Nebraska. Jun 1982
  • American Board of Pathology, Anatomic Pathology. Nov 11, 1980
  • Medical Licensure: Maryland. Oct 1980
  • Medical Licensure: Massachusetts. Aug 1978
  • National Board of Medical Examiners, Parts I and II. 1978
  • Licensure Medical Council of Canada. 1977
Selected Publications
  • Garmaroudi F, Marchant D, Hendry R, Luo H, Yang D, McManus BM. Coxsackievirus B3 (CVB3) replication and pathogenesis. Future Microbiol. Jan 2015. In Press.
  • Keire PA, Bressler SL, Lemire JM, Edris B, Rubin BP, Rahmani M, McManus BM, van de Rijn M, Wight TN. A role for versican in the development of leiomyosarcoma. J Biol Chem. 2014 Dec 5;289(49):34089-103.
  • Gunther O, Shin H, Ng R, McMaster R, McManus BM, Keown P, Tebbutt S, Le Cao K. Novel Multivariate Methods for Integration of Genomics and Proteomics Data: Applications in a Kidney Transplant Rejection Study. OMICS. 2014 Nov;18 (11):682-695.
  • Marchant D, Bellac C, Moraes T, Wadsworth Dufour S, Butler G, Bilawchuk L, Hendry R, Robertson G, Cheung C, Ng J, Ang L, Luo Z, Heilbron K, Norris M, Duan, Taylor B, Karpov A, Devel L, Georgiadis D, Hegele H, Luo H, Granville D, Dive V, McManus BM, Overall C.
    A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med. 2014 May;20(5):493-502.
  • Shannon C, Wilson-McManus, J, Balshaw R, Ng R, McMaster R, McManus BM, Keown P, Tebbut S. Two-stage, In Silico deconvolution of the lymphocyte compartment of the peripheral whole blood transcriptome in the context of acute kidney allograft rejection. PLoS ONE 2014 Apr 14;9(4):e95224.
  • Allahverdian S, Chehroudi AC, McManus BM, Abraham T, and Francis GA. Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation. 2014 Apr 15: 129:1551-1559.
  • Shin H, Shannon C, Fishbane N, Ruan J, Zhou M, Balshaw R, Wilson-McManus J, Ng R, McManus BM, Tebbutt S. Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion. PLoS One. 9(3):e91041, March 2014.
  • Shin H, Günther O, Hollander Z, Wilson-McManus J, Ng R, Balshaw R, Keown P,
    McMaster R, McManus BM, Isbel N, Knoll G, Tebbutt S. Longitudinal analysis of whole
    blood transcriptomes to explore molecular signatures associated with acute renal
    allograft rejection. Bioinform Biol Insights. 2014 Jan 228:17–33.
  • Hollander Z, Lazárová M, Lam K, Ignaszewski A, Oudit G, Dyck J, Schreiner G, Pauwels J, Chen V, Cohen Freue GV, Ng RT, Wilson-McManus JE, Balshaw R, Tebbutt S, McMaster RW, Keown PA, McManus BM. Proteomic biomarkers of recovered heart function. Eur J Heart Fail. 2014:16, 551–559.
  • Samadian S, McManus BM, Wilkinson M. Automatic detection and resolution of measurement-unit conflicts in aggregated data. BMC Medical Genomics. 2014, 7(Suppl 1):S12.
Research:
  • Cardiovascular & Pulmonary
  • Genomic Science
  • Immunology
  • Molecular Pathology
  • Current research activities center on injury and repair processes in inflammatory diseases of the heart and blood vessels:
    Inflammatory and viral basis of myocardial injury
  • Detection of viral infection
  • The role of immunomodulatory therapy in prevention of myocardial injury in human and animal model myocarditis and in allograft rejection
  • The pathobiology of heart allograft vasculopathy
  • Genomic, proteomic and metabolomic biomarkers of allograft rejection and of atherosclerosis
  • The progression to cardiomyopathic states
  • The genetic determinants and pathobiology of heart valve disease