My primary research is focused at investigating the genetic and physiological bases of immune system functioning and how it relays to immunological tolerance. The ability to discriminate self- from foreign-antigens is essential for both generating efficacious immune responses and avoiding the ravages of autoimmunity. My lab’s scientific themes will center on investigating immune functions in both human and mouse cells as a means of discovering novel therapies for autoimmune type 1 diabetes (T1D) and other forms of autoimmunity. A greater understanding of the immune system will lead to improved care for patients with primary Immunodeficiencies, autoimmune diseases and cancers. My work has been published in high impact journals such as Immunity, Blood and The Journal of Immunology and has been supported by the Canadian Institute of Health Research and the Juvenile Diabetes Research Foundation.