Academic Rank:
Professor
Affiliation(s):
Centre for Brain Health
Location:
Djavad Mowafaghian Centre for Brain Health

Short Bio:

Dr. Cheryl Wellington is a Professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia. Dr. Wellington has a unique niche of expertise that integrates research on genetic and environmental risk factors for dementia, with particular attention to metabolic and cardiovascular risk factors, cerebrovascular dysfunction, and traumatic brain injury (TBI). A major contribution to the TBI field includes the development of a novel animal model, known as CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration) of diffuse axonal injury that is particularly relevant for studies on the mechanisms of concussion. Dr. Wellington has published over 70 primary research papers, trained over 30 junior scientists in a dynamic multidisciplinary environment, and holds several leadership positions in the academic community.

Academic Backgrounds:
  • PhD, University of British Columbia, Microbiology. 1991
  • BSc, University of Alberta, Microbiology (1st Class Honors). 1985
Selected Publications
  • Tian LW, Feng Y, Shimizu Y, Pfeifer TA, Wellington C, Hooper JN, Quinn RJ, “1. ApoE secretion modulating bromotyrosine derivative from the Australian marine sponge Callyspongia sp.”, Bioorg Med Chem Lett, 24, 3537-3540. Aug 2014
  • S Stukas, J Robert, M Lee, I Kulic, N DeValle, M Carr, J Fan, D Namjoshi, K Lemke, J Chan, R Wilson, A Wilkinson, R Chapanian, JN Kizhakkedathu, MN Oda, CL Wellington, “5. Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus”, Journal of the American Heart Association, na, na. 2014/6 Published.
  • Vitali C, Wellington C, Calabresi L., “4. HDL and cholesterol handling in the brain”, Cardiovasc Res, na, na PMID: 24907980. 2014/6 Published.
  • Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR. ABCA1 influences neuroinflammation and neuronal death. Neurobiol Dis. 2013 Jun;54:445-55.
  • Namjoshi DR, Martin G, Donkin J, Wilkinson A, Stukas S, Fan J, Carr M, Tabarestani S, Wuerth K, Hancock RE, Wellington CL. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS One. 2013;8(1):e53529.
  • Hoekstra M, Korporaal SJ, van der Sluis RJ, Hirsch-Reinshagen V, Bochem AE, Wellington CL, Van Berkel TJ, Kuivenhoven JA, Van Eck M. LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function. J Lipid Res. 2013 Feb;54(2):358-64.
  • Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Curr Gerontol Geriatr Res. 2012;2012:179318.
  • Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function. Diabetes. 2012 Mar;61(3):659-64.
  • Stukas S, May S, Wilkinson A, Chan J, Donkin J, Wellington CL. The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1. Biochim Biophys Acta. 2012 Mar;1821(3):536-46.
  • Fan J, Stukas S, Wong C, Chan J, May S, DeValle N, Hirsch-Reinshagen V, Wilkinson A, Oda MN, Wellington CL. An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. J Lipid Res. 2011 Sep;52(9):1605-16.
  • Vila-Rodriguez F, Honer WG, Innis SM, Wellington CL, Beasley CL. ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype. J Psychiatry Neurosci. 2011 Jan;36(1):47-55.
  • Vila-Rodriguez F, Honer WG, Innis SM, Wellington CL, Beasley CL. ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype. J Psychiatry Neurosci. 2011 Jan;36(1):47-55.
  • Donkin JJ, Stukas S, Hirsch-Reinshagen V, Namjoshi D, Wilkinson A, May S, Chan J, Fan J, Collins J, Wellington CL. ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem. 2010 Oct 29;285(44):34144-54.
  • Valenza M, Leoni V, Karasinska JM, Petricca L, Fan J, Carroll J, Pouladi MA, Fossale E, Nguyen HP, Riess O, MacDonald M, Wellington C, DiDonato S, Hayden M, Cattaneo E. Cholesterol defect is marked across multiple rodent models of Huntington’s disease and is manifest in astrocytes. J Neurosci. 2010 Aug 11;30(32):10844-50. Aug 2010
  • Vila-Rodgriguez F, Honer WG, Inis SM, Wellington CL, Beasley CL. ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relationship with APOE genotype. J Psychiatry Neurosci, in press (2010). 2010
  • Takechi R, Galloway S, Pallebage-Gamarallage MM, Wellington CL, Johnsen RD, Dhaliwal SS, Mamo JC. Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. Br J Nutr. 2010 Mar;103(5):652-62. Epub 2009 Oct 28.
  • Karasinska JM, Rinninger F, Lütjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci. 2009 Mar 18;29(11):3579-89.
  • Parkinson PF, Kannangara TS, Eadie BD, Burgess BL, Wellington CL, Christie BR. Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1. Lipids Health Dis. 2009 Feb 24;8:5.
  • Hirsch-Reinshagen V, Burgess BL, Wellington CL. Why lipids are important for Alzheimer disease? Mol Cell Biochem. 2009 Jun;326(1-2):121-9.
  • Hirsch-Reinshagen V, Donkin J, Stukas S, Chan J, Wilkinson A, Fan J, Parks JS, Kuivenhoven JA, Lütjohann D, Pritchard H, Wellington CL. LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins. J Lipid Res. 2009 May;50(5):885-93.

 

View Dr. Wellington’s ResearchGate profile here

Research:
  • Neurodegeneration
  • Alzheimer’s Disease
  • Neurotrauma and neuronal repair
  • Lipids metabolism
  • Animal models of human disease
  • Pathology
  • Aging and Neurodegenerative Disease
  • Cardiovascular & Pulmonary
  • Neuroscience