Affiliation(s):
Blusson Spinal Cord Centre / ICORD and DMCBH
Location:
Blusson Spinal Cord Centre

Short Bio:

Dr. Laule completed her PhD in the Department of Physics & Astronomy (UBC) in 2005, after which she joined Dr. Alex MacKay’s team as a Research Associate in the Department of Radiology. Her graduate and post‐graduate work focused on developing and applying an in vivo MR marker for the measurement of myelin using quantitative T2 relaxation in human brain and spinal cord. In 2009 she was the inaugural recipient of the Women Against MS Transitional Career Development Award from the endMS Research and Training Network and the Multiple Sclerosis Society of Canada. This five year award ($500,000) funds two years of a post‐doctoral fellowship and the first three years of a junior faculty position at a Canadian university. Dr. Laule recently completed a post‐doctoral fellowship with Dr Wayne Moore in the Department of Pathology & Laboratory Medicine where her research focused on MRI‐pathology correlation studies in MS brain tissue.

Dr. Laule has been involved with NMR and MRI research for 16 years. She is interested in understanding the microstructural and pathological determinants which govern T1 and T2 relaxation measures in central nervous system (CNS) tissue. Her primary area of research is multiple sclerosis, but her interests extend to many other CNS applications including schizophrenia, cerebral malaria, bipolar disorder, leukodystrophies and Huntington’s disease, as well the characterization of normal controls across the life span.

For further information regarding Dr. Laule’s research, please visit her website, www.mripathology.ca.

Academic Backgrounds:
  • BSc (Major: Physics, Minor: German), University of British Columbia (1994-1999)
  • MSc (Physics), University of British Columbia (1999-2001)
  • PhD (Physics), University of British Columbia (2001-2005)
  • Research Associate, Department of Radiology, University of British Columbia (2005-2010)
  • Post doctoral fellowship, Department of Pathology & Laboratory Medicine, University of British Columbia (2010-2012)
Selected Publications
  • Meyers SM, Vavasour IM, Mädler B, Harris T, Fu E, Li DK, Traboulsee AL, Mackay AL, Laule C. Multicenter measurements of myelin water fraction and geometric mean T2 : Intra- and intersite reproducibility. Journal of Magnetic Resonance Imaging. 2013 Dec;38(6):1445-53 (senior author).
  • Zhang J, Kolind SH, Laule C, MacKay AL. Comparison of Myelin Water Fraction from Multi-echo T2 Decay Curve and Steady-state Methods. Magnetic Resonance in Medicine (in press, accepted December 18, 2013) (contributing author).
  • Wiggermann V, Hernandez Torres E, Vavasour IM, Moore GRW, Laule C, MacKay AL, Li DKB, Traboulsee AL, Rauscher A. Magnetic resonance frequency shifts during acute MS lesion formation. Neurology. 2013 Jul 16;81(3):211-8 (contributing author).
  • Zhang Y, Moore GRW, Laule C, Bjarnason TA, Kozlowski P, Traboulsee AL, Li DKB. Pathological correlates of MRI texture heterogeneity in multiple sclerosis. Annals of Neurology. Jul;74(1):91-9 (contributing author). Jul 2013
  • Bjarnason TA, Laule C, Bluman J, Kozlowski P. Temporal phase correction of multiple echo T2 magnetic resonance images. Journal of Magnetic Resonance. 2013 Jun;231:22-31 (contributing author).
Research:
  • MRI
  • brain & spinal cord
  • myelin
  • T1 and T2 relaxation
  • multiple sclerosis
  • CNS diseases
  • myelin water imaging
  • histology-MRI correlation