Academic Rank:
Associate Professor
MSFHR Scholar
Scientist Level 2, CFRI
Affiliation(s):
Child and Family Research Institute
Royal Columbian Hospital
Location:
Vancouver General Hospital

Short Bio:

My laboratory studies genomic abnormalities as the cause of human diseases. We use genomic microarrays to detect tiny chromosomal microdeletions and microduplications in patients with intellectual disability, autism or reproductive disorders. Most recently, we started using next generation sequencing to identify even smaller abnormalities in the DNA from our patients. Our current interest includes finding the functional consequences of gene copy number or sequence changes in patient cells and in animal models (e.g. zebrafish or C.elegans). Our ultimate goal is to understand better the connection between the phenotypic abnormalities in our patients and the defects in their genes.

Academic Backgrounds:
  • Michael Smith Foundation of Health Research Scholar, 2008-2014
  • CIHR Clinical Investigatorship, 2005-2009
  • Fellow of the Canadian College of Medical Genetics, subspecialty cytogenetics, 1998-present
  • CCMG Postdoctoral Fellowship (Clinical Cytogenetics), Children’s Hospital of Eastern Ontario, 1995-1997
  • Postdoctoral Fellow (Genetics) University of Ottawa, Ontario, 1993-1995
  • NSERC Visiting Fellowship, Agriculture Canada, Ottawa, 1991-1993
  • PhD, University of Belgrade, Yugoslavia, Molecular Cytogenetics. 1989
  • MSc, University of Belgrade, Yugoslavia, Cytogenetics. 1985
  • BSc, University of Novi Sad, Yugoslavia, Biology. 1983
Awards & Recognition:
  • CIHR Clinical Investigatorship salary award – 2005-2009
  • Michael Smith Foundation for Health Research, Career Scholar Award, 2008-2014
  • Fellow of the Canadian College of Medical Genetics (subspecialty cytogenetics), 1998
Selected Publications
  • Qiao Y, Mercier E, Dastan J, Hurlburt J, McGillivray B, Chudley AE, Farrell S,Bernier FP,Lewis MS(1), Pavlidis P, Rajcan-Separovic E. Copy number variants (CNVs) analysis in a deeply phenotyped cohort of individuals with intellectual disability (ID). BMC Med Genet. 2014 Jul 16;15:82. doi: 10.1186/1471-2350-15-82.
  • Reinthaler EM, Lal D, Lebon S, Hildebrand MS, Dahl HH, Regan BM, Feucht M,Steinböck H, Neophytou B, Ronen GM, Roche L, Gruber-Sedlmayr U, Geldner J,Haberlandt E, Hoffmann P, Herms S, Gieger C, Waldenberger M, Franke A, Wittig M, Schoch S, Becker AJ, Hahn A, Männik K, Toliat MR, Winterer G; 16p11.2 EuropeanConsortium, Lerche H, Nürnberg P, Mefford H, Scheffer IE, Berkovic SF, BeckmannJS; EPICURE Consortium; EuroEPINOMICS Consortium, Sander T, Jacquemont S, ReymondA, Zimprich F, Neubauer BA. 16p11 Jun 2014
  • Ying Qiao, Kajari Mondal,Valentina Trapani, Jiadi Wen, Gillian Carpenter, Robert Wildin, Magda E. Price, Richard J. Gibbons R, Jennifer Eichmeyer, Ruby Jiang, Barbara DuPont, Sally Martell, Suzanne M. E. Lewis, Wendy P. Robinson, Mark O’Driscoll, Federica I. Wolf, Michael E. Zwick, Evica Rajcan-Separovic   Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes. Human Mutation, 2014 Jan;35(1):58-62
  • Jiadi Wen , Fátima Lopes, Gabriela Soares, Sandra A. Farrell, Cara Nelson,Ying Qiao, Sally Martell, Chansonette Badukke, Carlos Bessa, Bauke Ylstra, Suzanne Lewis, Nina Isoherranen, Patricia Maciel, Evica Rajcan-Separovic Phenotypic and functional consequences of haploinsufficiency of genes from exocyst and retinoic acid pathway due to a recurrent microdeletion of 2p13.2. Orphanet Journal of Rare diseases, 8:100 (10 July 2013)
  • Wang P, Carrion P, Qiao Y, Tyson C, Hrynchak M, Calli K, Lopez-Rangel E, Andrieux J, Delobel B, Duban-Bedu B, Thuresson AC, Annerén G, Liu X, Rajcan-Separovic E, Suzanne Lewis ME. Genotype-phenotype analysis of 18q12.1-q12.2 copy number variation in autism.
    Eur J Med Genet. 2013 May 29. doi:pii: S1769-7212(13)00124-9. 10.1016/j.ejmg.2013.05.006.
  • Rassekh R and Evica Rajcan-Separovic: Comparative genomic hybridization of Wilms tumor, chapter in book entitled “CGH: Protocols, Applications and Technology Trends” (Methods in Molecular Biology, 2013;973:249-65).
  • Ying Qiao, Christine Tyson, Monica Hrynchak, Elena Lopez-Rangel, Jeanette Hildebrand, Sally Martell, Celina Fawcett, Levina Kasmara, Kristina Calli, Chansonette Harvard, Xudong, Liu, Jeanette J.A. Holden, M. E. Suzanne Lewis, Evica Rajcan-Separovic. Clinical application of 2.7M Cytogenetics array for CNV detection in subjects with idiopathic autism and/or intellectual disability, Clinical Genetics, 2013 Feb;83(2):145-54
  • Qiao Y, Tyson C, Hrynchak M, Lopez-Rangel E, Hildebrand J, Martell S, Fawcett C, Kasmara L, Calli K, Harvard C, Liu X, Holden J, Lewis S, Rajcan-Separovic E.Clinical application of 2.7M Cytogenetics array for CNV detection in subjects with idiopathic autism and/or intellectual disability. Clin Genet. 2012 Feb 27. doi: 10.1111/j.1399-0004.2012.01860.x. [Epub ahead of print].
Research:

My main research interests are genomic abnormalities as the cause of human diseases and translational medicine. We use exome sequencing to identify abnormalities in the DNA and genomic microarrays to detect tiny chromosomal microdeletions and microduplications in patients with intellectual disability, autism or reproductive disorders. To achieve our ultimate goal to understand better the connection between the phenotypic abnormalities in our patients and the defects in their genes we investigate the functional consequences of gene copy number or sequence changes in patient cells and in animal models.