Academic Rank:
Professor
Affiliated with Institute for Heart + Lung Health
Affiliation(s):
Centre for Heart Lung Innovation
Location:
James Hogg Research Centre

Short Bio:

Dr. Luo’s main research interests lie in the study of understanding the mechanisms leading to the pathogenesis of viral myocarditis. The focus of Dr. Luo’s research program is to define the pathogenetic determinants of virus-host interactions in enterovirus-induced heart disease. The ongoing research projects include: 1) Protein degradation pathways, including the ubiquitin/proteasome pathway and the autophagy, in virus-induced myocarditis; 2) The molecular mechanisms of impaired cardiac function in viral myocarditis, and 3) Host signaling mechanisms in viral myocarditis. Dr. Luo has published more than 70 refereed papers.Most of these publications have been appeared in leading journals, includingCirculation, Journal of Virology, Cell Death and Differentiation, Diabetes, Journal of Biological Chemistry, PNAS and Circulation Research.

Dr. Luo was a Canadian Institutes of Health Research/St. Paul’s Hospital Foundation New Investigator and a Michael Smith Foundation for Health Research Scholar. Dr. Luo was awarded a Canada Foundation for Innovation New Opportunities grant in acquiring cutting-edge infrastructure. Her work on the roles of protein degradation system and host signaling in virus-mediated myocarditis were supported by the Canadian Institutes of Health Research, the Heart & Stroke Foundation of Canada, and the Hospital for Sick Kids Foundation.

Academic Backgrounds:
  • MD, Chongqing Medical University, China, Medicine. 1986
  • MS, West China University of Medical Sciences, China, Hemodynamics. 1989
Selected Publications
  • Marchant D, Bellac C, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson G, Cheung C, Ng J, Ang L, Luo Z, Jeilbron K, Norris M, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM. A New Transcriptional Role for MMP12 in Antiviral Immunity. Nat Med. 2014; 20(5): 493-502 – CA (Impact factor: 28.054, Citations: 5).
  • Liu S, Lai L, Zou Q, Dao F. Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, Liao L, Luo H, Fu J, Liu M, Yi Z, Xiao J, Li X. PKA Turnover by the REGγ-Proteasome Modulates FoxO1 Cellular Activity and VEGF-Induced Angiogenesis. J Mol Cell Cardiol. 2014; 72: 28-38 – CA (Impact factor: 5.218, Citations: 0).
  • Shi J, Fung G, Piesik P, Zhang J, Luo H*. Dominant-Negative Function of the C-Terminal Fragments of NBR1 and SQSTM1 Generated during Enteroviral infection. Cell Death Differ. 2014; 34(2): 463-73 – SA (Impact factor: 8.385, Citations: 0).
  • Shravah J, Wang B, Pavlovic M, Kumar U, Chen D, Luo H, Ansley D. Propofol Mediates Signal Transducer and Activator of Transcription 3 Activation and Crosstalk with Phosphoinositide 3-kinase/AKT. JAKSTAT. 2014; 3: e2955 – CA (Impact factor: N/A).
  • Stepaniants S, Wang I, Boie Y, Mortimer J, Kennedy B, Elliott M, Hayashi S, Luo H, Wong J, Loy L, Coulter S, Roberts C, Hogg J, O’Neill G, Crackower M, Morris M, Obeidat M, Paré P. Genes Related to Emphysema Are Enriched for Ubiquitination Pathways. BMC Pulm Med. in press – CA (Impact factor: 2.489, Citations: 0). 2014
  • Jensen KJ, Garmaroudi FS, Zhang J, Lin J, Boroomand S, Zhang M, Luo Z, Yang D, Luo H, McManus BM*, Janes KA*. An ERK–p38 Subnetwork Coordinates Host Cell Apoptosis and Necrosis during Coxsackievirus B3 Infection. Cell Host Microbe.2013; 13: 67-76.
  • Choi A, Wong J, Marchant D, Luo H*. The Ubiquitin-Proteasome System in Positive-Strand RNA Virus Infection. Rev Med Virol. 2013; 23(2): 85-96– review – SA (Impact factor: 7.615).
  • Wong J, Si X, , Angeles A, Shi J, Fung G, Zhang J, Jagdeo J, Wang T, Zhong Z, Jan E, Luo H*. Cytoplasmic Redistribution and Cleavage of AUF1 during Coxsackieviral Infection Enhance Viral Replication. FASEB J. 2013; 27(7): 2777-87 – SA (Impact factor: 5.704).
  • Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Yang Z, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower L, Moses RE, Xiao J, O’Malley BW, Li X. REGγ Deficiency Promotes Premature Ageing via a CK1δ-Mdm2-p53 Pathway. Proc Natl Acad Sci U S A. 2013; 110(27): 11005-10 – CA (Impact factor: 9.737).
  • Shi J, Wong J, Pieski P, Fung G, Zhang J, Jagdeo J, Li X, Jan E, Luo H*. Cleavage of Sequestosome 1/p62 by an Enteroviral Protease Results in Disrupted Selective Autophagy and Impaired NFB Signaling. Autophagy. 2013 Aug 13; 9(10). [Epub ahead of print] – SA (Impact factor: 12.042).
Research:
  • Molecular mechanisms leading to viral myocarditis
  • Protein degradation system in cardiac remodeling