Academic Rank:
Assistant Professor
Affiliation(s):
Centre for Brain Health
Location:
UBC Hospital

Short Bio:

Dr. Jacqueline Quandt is the Associate Director of the UBC MS Research Group at UBC and leads the Neuroinflammation Lab at the Djavad Mowafaghian Centre for Brain Health and the Department of Pathology in the Faculty of Medicine. Her research is focused on understanding the role of the immune system in both damage and repair of the brain and spinal cord as a result of neurodegenerative diseases, such as Multiple Sclerosis. Using cell-based and more complex disease models, researchers in the Quandt Lab study the relationships between inflammation and neuronal death.

Academic Backgrounds:
  • BSc (Microbiology and Immunology), University of British Columbia. 1990-1994
  • PhD (Pathology, Section of Neuropathology), University of British Columbia. 1994-1999
  • Post doctoral fellowship (Neuroimmunology Branch), National Institutes of Health, Bethesda, MD. 1999-2005
  • Staff Scientist – Animal Models Unit (Neuroimmunology Branch), National Institutes of Health, Bethesda, MD. 2005-2009
Selected Publications
  • Yuen TF, Johnson K, Zhao C, Quandt J, McFarland HF, Franklin RBJ, ffrench-Constant C. Identification of endothelin-2 as an inflammatory factor that promotes CNS remyelination in the rodent. Brain 2013 Apr; 136(Pt 4):1035-47.
  • Quandt JA, Huh J, Baig M, Yao K, Ito N, Bryant M, Kawamura K, Pinilla C, McFarland HF, Martin R, Ito K. Humanized models support the etiologic role of DRB5*0101 in multiple sclerosis. J Immunol 2012 Sept;89;2897-2908.
  • Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJM, ffrench-Constant C. Identification of endothelin-2 as an inflammatory factor that promotes CNS remyelination. Brain in press. 2012
  • Li X, Johnson K, Bryant M, Elkahloun AG, Amar M, Remaley AT, De Silva R, Hallenbeck JM, Quandt JA. Intranasal Delivery of E-selectin Reduces Atherosclerosis in ApoE-/-Mice. PLOS one. 2011 6(6):e20620
  • Kawamura K, Yao K, Quandt JA, Huh J, Baig M, Quigley L, Ito N, Necker A, McFarland HF, Muraro PA, Martin R, Ito K. Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery. J Immunol. 2008 Oct 15;181(8):5462-72.
  • Cassiani-Ingoni R, Muraro PA, Magnus T, Reichert-Scrivner S, Schmidt J, Huh J, Quandt JA, Bratincsak A, Shahar T, Eusebi F, Sherman LS, Mattson MP, Martin R, Rao MS. Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response. J Neuropathol Exp Neurol. 2007 Jul;66(7):637-49.
  • Gelderblom H, Londoño D, Bai Y, Cabral ES, Quandt J, Hornung R, Martin R, Marques A, Cadavid D. High production of CXCL13 in blood and brain during persistent infection with the relapsing fever spirochete Borrelia turicatae. J Neuropathol Exp Neurol. 2007 Mar;66(3):208-17.
  • Gelderblom H, Schmidt J, Londoño D, Bai Y, Quandt J, Hornung R, Marques A, Martin R, Cadavid D. Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae. Am J Pathol. 2007 Jan;170(1):251-62.
  • Lünemann JD, Gelderblom H, Sospedra M, Quandt JA, Pinilla C, Marques A, Martin R. Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis. Infect Immun. 2007 Jan;75(1):243-51.
  • Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J. 2005 Sep 7;24(17):2968-79.
  • Quandt JA, Baig M, Yao K, Kawamura K, Huh J, Ludwin SK, Bian HJ, Bryant M, Quigley L, Nagy ZA, McFarland HF, Muraro PA, Martin R, Ito K. Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice. J Exp Med. 2004 Jul 19;200(2):223-34.
  • Anderson SA, Shukaliak-Quandt J, Jordan EK, Arbab AS, Martin R, McFarland H, Frank JA. Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis. Ann Neurol. 2004 May;55(5):654-9.
  • Shukaliak-Quandt J, Borras E, Prat E, Gelderblom H, Houghten RA, Kashani A, Pinilla C, Stuerzebecher CS, Martin R. Peptidic complex mixtures as therapeutic agents in CNS autoimmunity. Mol Immunol. 2004 Feb;40(14-15):1075-87.
  • Shukaliak-Quandt JA, Dorovini-Zis K, Wu V, Prameya R. The beta chemokines CCL4 and CCL5 enhance adhesion of specific CD4+ T cell subsets to human brain endothelial cells (HBMEC) in vitro. J Neuropath Exp Neurol 2004 63:350-362.
Current Projects in My Lab Include:

The Laboratory currently has openings for a graduate student and a post doctoral fellow to pursue independent projects in the areas of neuroinflammation and models of disease. Interested candidates should send their CV and statement of research interests directly to Dr. Quandt.

Research:
  • Neuroimmunology
  • In vitro models of the blood-brain barrier
  • T cell/Blood-brain barrier interactions & trafficking
  • Animal models of CNS demyelinating disease/autoimmunity
  • Development of novel therapeutics to afford neuroprotection
  • Immunology
  • Antigen specificity/degeneracy of T cells
  • Antigen-specific tolerance