Academic Rank:
Adjunct Professor
Affiliation(s):
James Hogg Research Centre
Location:
James Hogg Research Centre

Short Bio:

Dr. John Hill received his undergraduate (BMLSc) and graduate training (MSc, PhD) at UBC in the Faculty of Medicine within the Department of Pathology and Laboratory Medicine ending in 1994. He completed a three-year postdoctoral fellowship in the Lipid Research Laboratory at UCLA in Los Angeles before beginning his appointment at UBC in the Department of Pathology and Laboratory Medicine in January 1998.

Dr. Hill was the Director of the Atherosclerosis Specialty Laboratory of the Healthy Heart Program at St. Paul’s Hospital from 2000-2013. His research program was concerned with lipid and lipoprotein research and its relationship with coronary artery disease.

Currently, Dr. Hill is an Adjunct Professor providing lecture and educational support for a variety of activities at UBC.

Academic Backgrounds:
  • Post-doctoral Fellow, UCLA, Los Angeles, CA. 1997
  • PhD, University of British Columbia, Pathology Lab Medicine. 1994
  • MSc, University of British Columbia, Pathology Lab Medicine. 1990
  • BMLSc, University of British Columbia, Pathology Lab Medicine. 1988
Selected Publications
  • Nurit Fox, Najib Ayas, Julie E. Park, John Fleetham, C. Frank Ryan, Scott A. Lear, Alan Mulgrew, Sammy Chan, John Hill, G. B. John Mancini, Graham C. Wong. Carotid Intima Media Thickness in Patients with Obstructive Sleep Apnea: Comparison with a Community-Based Cohort. Lung. 2014 (in press).
  • Yang, Peng, Belikova, Natalia, Billheimer, Jeff, Rader, Daniel J, Hill, John S, Subbaiah, Papasani V. Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins. Lipids. 2014 (in press).
  • Dominik Domanski, Andrew J. Percy, Juncong Yang, Andrew G. Chambers, John S. Hill, Gabriela V. Cohen Freue, and Christoph H. Borchers. MRM-based Multiplexed Quantitation of 67 Putative Biomarkers of Cardiovascular Disease in Human Plasma. 2012. Proteomics 12: 1222-43.
  • Claire L Heslop, Scott J Tebbutt, Mohua Podder, Jian Ruan, and John S Hill. Combined polymorphisms in oxidative stress genes predict coronary artery disease and oxidative stress in coronary angiography patients. American Journal of Human Genetics. 2012, 76:435-447.
  • Eliane Picard-Deland, Charles Lavigne, Julie Marois, Julie Bisson, S. John Weisnagel, Andre Marette, Bruce Holub, Eugene Chu, Jiri Frohlich, John S. Hill, and Helene Jacques. Dietary supplementation with fish gelatin modifies nutrient intake and leads to sex-dependent responses in plasma triglyceride concentrations of insulin-resistant subjects. Journal of Nutritional Science. 2012 1:e15.
  • Eugene M. Chu, Daven C. Tai, Jennifer L. Beer, and John S. Hill . Macrophage heterogeneity and cholesterol homeostasis: Classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL. Biochmica et Biophysica Acta: Molecular and Cell Biology of Lipids. 2012, 1831: 378-386.
  • Hill JS, Heslop C, Man SFP, Frohlich J, Connett JE, Anthonisen NR, Wise RA, Tashkin DP, Sin DD. Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality. Eur Heart J 2011 32:1918-25
  • Edelstein C, Pfaffinger D, Yang M, Hill JS, Scanu AM. Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Biochim Biophys Acta. 2010 Jul;1801(7):738-45. Epub 2010 Mar 24.
  • Heslop C, Frohlich JJ, Hill JS. Myeloperoxidase and C-reactive protein have combined utility for long term prediction of cardiovascular mortality after coronary angiography. J Am Coll Cardiol. 2010 Mar 16;55(11):1102-9.
Research:
  • Blood Research
  • Cardiovascular & Pulmonary
  • Biochemistry and molecular biology of lipids and lipoprotein metabolism, macrophage biology, cardiovascular biomarkers and atherosclerosis
  • Discovery of novel biomarkers for cardiovascular disease
  • Study of the macrophage as a therapeutic target for atherosclerosis
  • Lipid and lipoprotein metabolism in the normal population and in individuals with inherited genetic defects