Child and Family Research Institute
Children’s & Women’s Health Centre of BC
Academic Backgrounds:
  • PhD, University of British Columbia, Biomedical Research Centre ) then moved with advisor to Howard Hughes Medical Institute, University of California San Diego, (Genetics Program). 1990 – 1997
  • BSc, University of British Columbia, (Microbiology & Immunology). 1985 – 1989
Selected Publications

  • Klein T, Fung S-Y, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scuril J, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE and Overall CM. (2015) The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signaling. Nature Communications 6, 8777. PMID: 26525107.
  •  Montane J, Obach M, Alvarez S, Bischoff L, Dai DL, Soukhatcheva G, Priatel JJ, Hardenberg G, Levings MK, Tan R, Orban PC and Verchere CB. (2015) CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance. Cell Transplantation 24, 2143-2154. PMID: 26423995
  • Chung BK, Priatel JJ, Tan R. (2015) CD1d expression and invariant NKT cell responses in herpesvirus infections. Frontiers in Immunology 6, 312. eCollection 2015. PMID: 26161082.
  • van Luijn MM, Kreft KL, Jongsma ML, Mes SW, Wierenga-Wolf AF, van Meurs M, Melief MJ, van der Kant R, Janssen L, Janssen H, Tan R, Priatel JJ, Neefjes J, Laman JD and Hintzen RQ. (2015) Multiple Sclerosis-Associated CLEC16A Controls HLA Class II Expression via Late Endosome Biogenesis. Brain 138, 1531-1547. PMID: 25823473.
  • Huang YH, Tsai K, Ma C, Vallance BA, Priatel JJ # and Tan R #. (2014) SLAM/ SAP signaling promotes the differentiation of IL-17 producing T cells and progression of experimental autoimmune encephalitis. The Journal of Immunology 193, 5841-5853. PMID: 25362182. Number sign (#) indicates that JJP and RT are co-senior and corresponding authors
  • Roberts ME, Bishop JL, Fan X, Beer JL, Kum WW, Krebs DL, Huang M, Gill N, Priatel JJ, Finlay BB and Harder KW. (2014) Lyn Deficiency Leads to Increased Microbiota-Dependent Intestinal Inflammation and Susceptibility to Enteric Pathogens. The Journal of Immunology 193, 5249-5263. PMID: 25339668.
  • Priatel JJ *, Chung BK, Tsai K and Tan R*. (2014) NKT Cell Based Strategies to Combat EBV Infection. OncoImmunology Apr 9;3:e28329. eCollection 2014.  PMID: 25050206.
    Asterisk (*) designates that JJP and RT are corresponding authors.
  • McKinnon ML, Rozmus J., Fung SY, Hirschfeld AF, Del Bel KL, Thomas L, Marr N, Martin SD, Marwaha AK, Priatel JJ, Tan R, Senger C, Tsang A, Prendiville J, Junker AK, Seear M, Schultz KR, Sly LM, Holt RA, Patel MS, Friedman JM, and Turvey SE. (2014) Combined Immunodeficiency Associated with Homozygous MALT1 Mutations. The Journal of Allergy and Clinical Immunology 133, 1458-1462. PMID: 24332264.
  • Chung BK, Tsai K, Allan LL, Zheng DJ, Nie JC, Biggs CM, Kozak FK, van den Elzen P, Priatel JJ # and Tan R #. (2013) Innate immune control of EBV-infected B cells by invariant natural killer T cells. Blood 122, 2600-2608. PMID: 23974196. Number sign (#) indicates that JJP and RT contributed equally.
  • Krebs DL, Chehal MK, Sio A, Huntington ND, Da ML, Ziltener P, Priatel JJ, Anderson GP, Tarlinton DM, Hibbs ML and Harder KW. (2012) The Lyn Tyrosine Kinase Regulates the Innate Immune Response by Controlling Dendritic Cell Maturation, Cytokine Production and Natural Killer Cell Activation. The Journal of Immunology 188, 5094-5105. PMID: 22491248.
  • Veerman KM, Carlow DA, Shanina I, Priatel JJ, Horwitz MS and Ziltener HJ. (2012) PSGL-1 regulates the migration and proliferation of CD8+ T cells under homeostatic conditions. The Journal of Immunology 188, 1638-1646. PMID: 22250093.
  • Lee I-F, van den Elzen P, Tan R and Priatel JJ. (2011) Natural Killer T Cells Are Required for CFA-mediated Protection from Autoimmune Diabetes. The Journal of Immunology 187, 2898–2904. PMID: 21844383.
  • Omilusik K, Priatel JJ #, Chen X, Wang YT, Xu H, Choi KB, Gopaul R, McIntyre-Smith A, Teh H-S, Tan R, Bech-Hansen NT, Waterfield D, Fedida D, Hunt SV, and Jefferies WA. (2011) The CaV1.4 Calcium Channel is a Critical Regulator of T Cell Receptor Signaling and Naïve T Cell Homeostasis. Immunity (Cell Press) 35, 349-360. PMID: 21835646. Number sign (#) indicates co-first authorship.
  • Qin H, Lee I-F, Panagiotopoulos C, Wang X, Chu AD, Utz PJ, Priatel JJ # and Tan R #. (2011) Natural Killer Cells from Children with Type 1 Diabetes Have Defects in NKG2D-dependent Function and Signaling. Diabetes 60, 857-866. PMID: 21270236. Number sign (#) indicates that JJP and RT are cosenior authors
  • Marwaha AK, Crome SQ, Panagiotopoulos C, Qin H, Ouyang Q, Xu L, Priatel JJ, Levings MK and Tan R. (2010) Cutting Edge: Increased IL-17 Secreting T Cells in Children with New-Onset Type 1 Diabetes. The Journal of Immunology 185, 3814–3818. PMID: 20810982.
  • Priatel JJ *, Chen X, Huang YH, Chow MT, Zenewicz LA, Coughlin JJ, Shen H, Stone JC, Tan R, Teh HS. (2010) RasGRP1 Regulates Antigen-induced Developmental Programming by Naive CD8 T Cells. The Journal of Immunology 184, 666-676. PMID: 20007535. Asterisk (*) indicates corresponding author.
  • Chen, X, Priatel JJ, Chow, MT and Teh, HS. (2008) Preferential Development of Functional CD4 and CD8 Regulatory T Cells in RasGRP1-Deficient Mice. The Journal of Immunology 180, 5973-5982. PMID: 18424717.
  • Lee, IF, Qin H., Priatel JJ and Tan R. (2008) Critical Role for Interferon-γ in Natural Killer Cell Mediated Protection from Diabetes. European Journal of Immunology 37, 32-39.
  • PMID: 18085661.
  • Priatel JJ, Chen X, Zenewicz L.A, Shen H, Harder KW, Horwitz MS and Teh HS. (2007) Chronic Immunodeficiency in Mice Lacking RasGRP1 Results in CD4 T Cell Immune Activation and Exhaustion. The Journal of Immunology 179, 2143-2152. PMID: 17675473.
  • Osborne LC, Dhanji S, Snow JW, Priatel JJ, Ma MC, Miners MJ, Teh HS, Goldsmith MA and Abraham N. (2007) Impaired CD8 T Cell Memory and CD4 T Cell Primary Responses in IL-7Ra Mutant Mice. The Journal of Experimental Medicine 204, 619-631. PMID: 17325202.

My primary research is focused at investigating the genetic and physiological bases of immune system functioning and how it relays to immunological tolerance. The ability to discriminate self- from foreign-antigens is essential for both generating efficacious immune responses and avoiding the ravages of autoimmunity. My lab’s scientific themes will center on investigating immune functions in both human and mouse cells as a means of discovering novel therapies for autoimmune type 1 diabetes (T1D) and other forms of autoimmunity. A greater understanding of the immune system will lead to improved care for patients with primary Immunodeficiencies, autoimmune diseases and cancers. My work has been published in high impact journals such as Immunity, Blood and The Journal of Immunology and has been supported by the Canadian Institute of Health Research and the Juvenile Diabetes Research Foundation.